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PHARMACEUTICAL USES OF TERPENOIDS

The terpenoids , sometimes called isoprenoids, are a large and diverse class of naturally-occurring organic chemicals similar to terpenes, derived from  five-carbon isoprene units assembled and modified in thousands of ways. Terpenes are hydrocarbons resulting from the combination of several isoprene units. Terpenoids can be thought of as modified terpenes, wherein methyl groups have been moved or removed, or oxygen atoms added.

Terpene biosynthesis

Terpenoids are vital for life of most organisms in exerting metabolic control and in mediating intra- and inter-species interactions, for example, pollination and defense in plants. In plant terpenoid biosynthesis two different pathways synthesize the main building block, isopentenyl diphosphate (IPP) (fig. 1); the methylerythritolphosphate (MEP) pathway (also named 1-deoxy-D-xylulose (DOX) pathway)  in the chloroplast forms IPP for mono- and diterpenoids, and the mevalonic acid (MVA) pathway in the cytosol, produces IPP for sesquiterpenoids.

USES

A method of medical treatment for a medical condition in a mammal, said condition being selected from the group consisting of viral infections, bacterial infections, fungal infections, dermatoses, indolent neoplasms, sunburn, burns and swollen joints, said method comprising the parenteral application to said mammal of a pharmacologically effective amount for treatment of said condition of an ozonide of a termpene in a pharmacologically acceptable carrier or excipient.

                         The method of claim 1, wherein said terpene is selected from the group consisting of limonene, citronella, alphacarotene, beta-carotene, Vitamin A, linalool, linalyl acetate, squalene, geraniol, limonene, alpha-pinene, loganin, cymeme, farnesanes, eudesmanes, acoranes, cedranes, chamigranes, caryophyllanes, illudanes, humulenes, himachalenes, longifolanes, perhydroazulenes, quaianes, quaianolides, germacranes, labdane, clerodanes, abietic acid, phyllocladene, giberellins, ophiobolin A, retigeranic acid, gasgardic acid, lanosterol, euphol, oleanane, ursane, lupeol, hydroxyhopanone, lupanes, hopanes, B-selinene, zingibene, camphene, sabinene, ocimene, myrcene, nerol, citral A, citral B,. farnesol, bisabolene, phytol, and cecropia juvenile hormone.

                    A pharmaceutical composition for the treatment of a medical condition in a mammal, comprising pharmaceutically effective amounts for treatment of said condition of an ozonide of a terpene in a pharmaceutically acceptable injectable carrier.
                  A pharmaceutical composition for the treatment of a medical condition in a mammal, comprising pharmaceutically effective amounts for treatment of said condition of an ozonide of a terpene in a pharmaceutically acceptable carrier for parenteral administration.
               A method of treating fungal, bacterial, or viral infections in a mammal by administering an effective amount of a composition. A method of treating fungal infections of the skin or nails by administering an effective amount of a composition.

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Categories: MEDICINAL CHEMISTRY
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